Custom LDN for Autoimmune Diseases

Personalised Low Dose Naltrexone therapy to help regulate your immune system and reduce flares—without immune suppression.

 

Calm the Immune Storm with Custom LDN

Living with an autoimmune condition can feel like your body is working against you. Whether it’s Hashimoto’s, lupus, rheumatoid arthritis, or Crohn’s, the fatigue, flares, and unpredictable symptoms can take a real toll, not just physically, but emotionally too. And when your immune system is attacking healthy tissues, you deserve more than a one-size-fits-all solution.

That’s why, at Alpine Pharmacy, we offer custom-compounded Low-Dose Naltrexone (LDN), tailored to your specific condition, dosing needs, and tolerance. Whether you're managing flares, chronic fatigue, or stubborn inflammation, our personalised approach helps support immune balance—gently and precisely.

Our custom LDN formulations are prepared in a USP <795>-compliant compounding lab, using pharmaceutical-grade ingredients with allergen-free options. We work directly with your provider—or help connect you to one—so your immune support plan fits your body, not a standard protocol.

 Start a custom LDN plan built for your autoimmune needs.

SCHEDULE A CONSULTATION TODAY!
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How Common Are Autoimmune Conditions?

25% of patients often deal with multiple autoimmune conditions, not just one

These chronic illnesses often include joint pain, chronic fatigue, brain fog, digestive issues, and anxiety, and these are areas where customised LDN formulations may offer symptomatic relief.

Why You Need to Balance Your Immune System - Not Suppress It!

In autoimmune diseases, your immune system mistakenly attacks healthy tissues. Steroids and immunosuppressants may help, but they often blunt your immune system entirely, increasing the risk of infections and long-term side effects.

 

LDN offers a different approach

Instead of shutting down your immune system like steroids or immunosuppressants do, Low Dose Naltrexone helps rebalance it. It gently resets how certain immune cells communicate, calming the inflammation without leaving you vulnerable to infections.

It does this by interacting with parts of your nervous and immune systems (called opioid and Toll-like receptors), helping your body reduce harmful overreactions while still defending you when it needs to.

How LDN Works in Autoimmune Conditions

When taken in low doses (0.5–4.5 mg/day), custom formulations of Low Dose Naltrexone help your body rebalance its immune response in three essential ways:

1. Boosts Feel-Good Chemicals (Endorphins)

LDN briefly blocks opioid receptor sites in the brain, which then triggers your body to produce more natural endorphins, like β-endorphin and enkephalins. These chemicals not only reduce pain but also help calm the immune system.

2. Calms Inflammatory Brain Cells (TLR4 Inhibition)

 Certain brain and immune cells, like microglia and macrophages, can drive chronic inflammation when active. Low-dose naltrexone helps “turn down” a key trigger called TLR4. This tells those cells to stop overreacting, reducing inflammation.

3. Supports Immune “Peacemakers” (Regulatory T Cells)

 Autoimmune disease often involves T-cells mistakenly attacking your own body. LDN has been shown in lab studies to support the function of regulatory T cells, which help calm those attacks and prevent flare-ups. For example, in an animal model of multiple sclerosis, LDN reduced the types of T-cells that drive damage.

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When it comes to autoimmune support or chronic pain management, one-size-fits-all medication often falls short. Alpine Compounding Pharmacy in Arvada, Colorado, provides custom LDN medications for relief from autoimmune diseases.

→ Want to understand LDN basics first?

LDN Can Help with a Range of Autoimmune Conditions

Thyroid & Hormonal
✔️ Hashimoto’s Thyroiditis
✔️ Graves’ Disease
✔️ Type 1 Diabetes
✔️ Polycystic Ovary Syndrome (PCOS)
✔️ Endometriosis (immune-mediated subtype)
Gut & Digestive
✔️ Crohn’s Disease
✔️ Ulcerative Colitis
✔️ Celiac Disease
✔️ Autoimmune Hepatitis
Joints & Musculoskeletal
✔️ Rheumatoid Arthritis (RA)
✔️ Psoriatic Arthritis
✔️ Ankylosing Spondylitis
✔️ Scleroderma (Systemic Sclerosis)
✔️ Dermatomyositis / Polymyositis
Neurological & Nerve-Related
✔️ Multiple Sclerosis (MS)
✔️ Myasthenia Gravis
✔️ Autoimmune Encephalitis
✔️ Chronic Fatigue Syndrome (ME/CFS)
✔️ Fibromyalgia
✔️ Long COVID (immune dysregulation)
Skin & Mucosal
✔️ Psoriasis
✔️ Lichen Planus
✔️ Vitiligo
✔️ Atopic Dermatitis (Eczema)
✔️ Systemic Lupus Erythematosus (SLE)
Eyes & Glands
✔️ Sjögren’s Syndrome
✔️ Autoimmune Uveitis

LDN for Symptom Relief in Autoimmune Disease

  • Symptom

  • Common Patient Feedback

    • Joint pain

    • Less stiffness in the morning, reduced need for NSAIDs

      • Fatigue

      • Better energy levels and improved endurance

        • Brain fog

        • Sharper thinking and fewer memory lapses

          • Mood

          • Reduced anxiety and emotional reactivity

            • Sleep

            • Deeper, more restful sleep cycles

              • Flares

              • Longer gaps between symptom flares or intensity

                Ideal Candidates for Compounded LDN in Autoimmunity

                You may benefit from LDN if you:

                • Are living with one or more diagnosed autoimmune diseases
                • Are  tapering off steroids or seeking a complementary therapy
                • Have tried multiple medications with limited success
                • Want a gentler, long-term inflammation management option

                LDN may be especially useful for those with:

                • Steroid allergies or sensitivities 
                • Chronic overlapping symptoms (e.g., thyroid + joint + gut)
                • Fatigue and brain fog without clear lab abnormalities

                What Makes Alpine’s LDN Compounding Different

                We’re more than a compound medication dispensary—we’re your treatment partner.
                 At Alpine Compounding Pharmacy, we:

                • Work directly with your physician or help connect you to a prescriber
                • Offer multiple forms: capsules, sublingual drops, troches, and liquids
                • Use dye-free, gluten-free, and preservative-free bases
                • Adjust your dosage based on tolerability and effect (common starting dose: 1.5 mg)
                • Support you with ongoing pharmacist check-ins if needed

                How to Get Started with LDN for Autoimmune Conditions

                1. Talk to your doctor or reach out to us to help connect you with a prescriber
                2. We compound your prescription with precise dosing
                3. Choose your preferred format—we’ll help you find the easiest fit

                Begin therapy with support—we’ll guide you through your first dose and titration.

                -->Meet our pharmacists

                Frequently Asked Questions (FAQ): LDN for Autoimmunity

                1Can I use LDN while on methotrexate or steroids?
                Yes, many patients use LDN alongside conventional immunosuppressants under physician supervision.
                2Will it interfere with my thyroid medication?
                No, but thyroid doses may need adjustment if LDN improves autoimmunity markers (like TPO antibodies). Your doctor can monitor this.
                3Can LDN help with overlapping autoimmune conditions (e.g., RA + Hashimoto’s)?
                Yes. Because LDN targets broad immune pathways, it’s often helpful in patients with multiple conditions.
                4Are there side effects specific to autoimmune patients?
                No specific risks, but some may experience mild sleep disturbances or vivid dreams initially.
                5Is it suitable for long-term use?
                Yes, LDN has shown good tolerability in long-term use across multiple studies.
                6Can low-dose naltrexone reverse autoimmune disease?
                No, LDN cannot cure or reverse autoimmune conditions. However, it can help regulate immune function, reduce symptom flares, and improve quality of life in many chronic autoimmune diseases.
                7How is LDN different from biologics for autoimmune disease?
                Biologics (like Humira or Enbrel) are targeted immune suppressors with strong effects and strong risks. LDN modulates immunity more gently and doesn’t raise the risk of infection. It can also be used alongside biologics in some cases.
                8Can I take LDN if I have more than one autoimmune disease?
                Yes. Many patients with conditions like lupus, Sjögren’s, and Hashimoto’s benefit from LDN’s broad-spectrum immune modulation.
                9Will LDN help with autoimmune fatigue or brain fog?
                Many patients report reduced fatigue and improved cognitive clarity within weeks of starting LDN. This is likely due to decreased neuroinflammation and better endorphin regulation.
                10Is LDN safe to use during autoimmune pregnancy?
                The safety of LDN in pregnancy has not been widely studied. Some physicians may allow use in certain cases (e.g., Hashimoto’s), but always consult your OB-GYN or specialist before starting.
                11Will I need to taper off LDN?
                Most patients do not experience withdrawal and can stop LDN without tapering. However, any changes to medication should be made under medical supervision.
                12Is there a difference between LDN capsules and liquid for autoimmune diseases?
                Both are effective, but liquid or sublingual forms allow for easier microdosing and gradual titration, often helpful in sensitive autoimmune patients.

                Let’s Build a Plan That Works With Your Body

                If you’re living with an autoimmune condition or chronic pain, you know how frustrating it is to try treatment after treatment, only to face new side effects or limited relief. That’s why more people are turning to personalised Low Dose Naltrexone (LDN). 

                At Alpine Compounding Pharmacy, we specialise in custom-compounded LDN prescriptions—tailored to your condition, your dose, and your body’s needs.

                Custom-compounded LDN shipped discreetly to your door

                At Alpine Compounding Pharmacy, we specialise in custom-compounded LDN prescriptions—tailored to your condition, your dose, and your body’s needs.

                SCHEDULE A CONSULTATION TODAY!
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